fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity
Results show that aqueous C60 suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage.
A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties
Antioxidant Effect of C60 and C70 Fullerene in the Autoxidation of Ethyl Oleate
Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons
C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation
Effects of Pin-up Oxygen on Fullerene for Enhanced Antioxidant Activity
The introduction of pin-up oxygen on C60, such as in the oxidized fullerenes C60O and C60On, induced noticeable increase in the antioxidant activity as compared to pristine C60. The water-soluble inclusion complexes of fullerenes C60O and C60On reacted with linoleic acid peroxyl radical 1.7 and 2.4 times faster, respectively.
Fullerene-based antioxidants and neurodegenerative disorders
The malonic acid C60 derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H2O2, and were effective inhibitors of lipid peroxidation, as well. Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures.
Fullerenes as Anti-Aging Antioxidants
Hepatoprotective effect of orally applied water-soluble pristine C60 fullerene against CCl4-induced acute liver injury in rats
High anti-oxidation power
Fullerene's anti-oxidative ability is 172 times more effective than vitamin C.
Interaction of C(60) fullerene with lipids
Unmodified hydrated С60 fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress